I am interested in neural plasticity, specifically how the adult brain changes its structure in response to altered sensory input. My model system is the zebrafish olfactory system. For over 20 years I have been exploring the potential of the adult zebrafish olfactory bulb to recover from injury and disease.

I am also fascinated by developmental processes, and I am fortunate enough to work in a part of the nervous system that is continually developing. The olfactory system is amazing in that the peripheral organ exhibits neuronal turnover and the olfactory bulb is one of the very few places in the adult brain that has persistent neurogenesis. How cool is that?



Dendritic Plasticity

How does sensory input maintain dendrite structure?

  • BS Biology, 1982, Avila College

  • PhD Molecular and Cellular Biology, 1992, University of Arizona

  • Postdoc, 1992-96, University of Virginia

  • Assistant Professor, 1996-2002, WMU

  • Associate Professor, 2002-2009, WMU

  • 2009-present- Professor, WMU

  • 2014-2019- Associate Dean, Graduate College, WMU

  • 2019-2020- Interim Dean, Graduate College, WMU

  • 2020-present- Dean, Graduate College, WMU 


How does the immune response to brain damage affect neural regeneration?

Olfactory Toxicity

How do chemical toxicants affect olfactory organ structure and function?

Adult Neurogenesis

How does the olfactory bulb recover from deafferentation?


Refereed Journal Articles:

Var, S.R. and C.A. Byrd-Jacobs. 2020. Role of macrophages and microglia in zebrafish regeneration. International Journal of Molecular Sciences in press.


Scheib, J.J. and C.A. Byrd-Jacobs. 2020. Zebrafish astroglial morphology in the olfactory bulb is altered with repetitive peripheral damage. Frontiers in Neuroanatomy 14:article 4; doi 10.3389.fnana.2020.00004.


Var, S.R. and C.A. Byrd-Jacobs. 2019. Microglial response patterns following damage to the zebrafish olfactory bulb. IBRO Reports 7:70-79.

Calvo-Ochoa, E. and C.A. Byrd-Jacobs. 2019. The olfactory system of zebrafish as a model for the study of neurotoxicity and injury: implications for neuroplasticity and disease. International Journal of Molecular Sciences 20(7), 1639; https://doi.org/10.3390/ijms20071639.

Pozzuto, J.M., C. L. Fuller, and C.A. Byrd-Jacobs. 2019. Deafferentation-induced alterations in mitral cell dendritic morphology in the adult zebrafish olfactory bulb. Journal of Bioenergetics and Biomembranes 51:29-40 doi.org/10.1007/s10863-018-9772-x


Scheib, J.J., J.M. Pozzuto, and C.A. Byrd-Jacobs. 2019. Reversible deafferentation of the zebrafish olfactory bulb with wax plug insertion. Journal of Neuroscience Methods 311:47-56.

Hentig, J.T. and C.A. Byrd-Jacobs. 2016. Exposure to zinc sulfate results in differential effects on olfactory sensory neuron subtypes in adult zebrafish. International Journal of Molecular Sciences 17:1445-1459.


Trimpe, D.M. and C.A. Byrd-Jacobs. 2016. Patterns of olfactory bulb neurogenesis in the adult zebrafish are altered following reversible deafferentation. Neuroscience 331:134-147.


White, E.J., S.K. Kounelis, and C.A. Byrd-Jacobs. 2015. Plasticity of glomeruli and olfactory-mediated behavior in zebrafish following detergent lesioning of the olfactory epithelium. Neuroscience 284:622-631.


Paskin, T.R. and C.A. Byrd-Jacobs. 2012. Reversible deafferentation of the adult zebrafish olfactory bulb affects glomerular distribution and olfactory-mediated behavior. Behavioural Brain Research 235:293-301.


Paskin, T.R., T.R. Iqbal, and C.A. Byrd-Jacobs. 2011. Olfactory bulb recovery following reversible deafferentation with repeated detergent application in the adult zebrafish. Neuroscience 196:276-284.


Iqbal, T. and C.A. Byrd-Jacobs. 2010. Rapid degeneration and regeneration of the zebrafish olfactory epithelium after Triton X-100 application. Chem. Senses 35:351-361.


Villanueva, R. and C.A. Byrd-Jacobs. 2009. Peripheral sensory deafferentation affects olfactory bulb neurogenesis in zebrafish. Brain Research 1269:31-39.


Suhr, S.T., R. Ramachandran, C.L. Fuller, M.B. Veldman, C.A. Byrd, and D. Goldman. 2009. Highly restricted, cell-specific expression of the simian CMV-IE promoter in transgenic zebrafish with age and after heat shock. Gene Expr. Patterns 9:54-64.


Fuller, C.L., H.K. Yettaw, and C.A. Byrd. 2006. Mitral cells in the olfactory bulb of adult zebrafish, Danio rerio: Morphology and distribution. J. Comp. Neurol. 499:218-230.


Bushrow, E.S., C.L. Fuller, D.P. Cowan, and C.A. Byrd. 2006. Anatomy of the male reproductive system and sperm morphology in the caterpillar hunting wasp, Ancistrocerus antilope (Hymenoptera: Vespidae). Invertebrate Biology 125(4):354-362.


Fuller, C.L. and C.A. Byrd. 2005. Ruffed cells identified in the adult zebrafish olfactory bulb. Neurosci. Lett. 379(3):190-194.


Fuller, C.L., R. Villanueva, and C.A. Byrd. 2005. Changes in glutamate receptor subunit 4 expression in the deafferented olfactory bulb of zebrafish. Brain Research 1044(2):251-261.


VanKirk, A.M. and C.A. Byrd. 2003. Apoptosis following sensory deafferentation in the olfactory bulb of adult zebrafish. J. Comp. Neurol. 455:488-498.


Byrd, C.A. and P.C. Brunjes. 2001. Neurogenesis in the olfactory bulb of adult zebrafish.  Neuroscience 105:793-801


Byrd, C.A. 2000. Deafferentation-induced changes in the olfactory bulb of adult zebrafish. Brain Research 866:92-100.


Byrd, C.A. and P.C. Brunjes. 1998. Addition of new cells to the olfactory bulb of adult zebrafish.  Proceedings of the International Symposium on Olfaction and Taste XII. In: Annals of the New York Academy of Sciences 855: 274-276.


Vogt, R.G., S.M. Lindsay, C.A. Byrd, and M. Sun. 1997. Spatial patterns of olfactory neurons expressing specific odor receptors in 48-hour-old embryos of zebrafish Danio rerio. J. Experimental Biology 200:433-443.


Byrd, C.A., J.T. Jones, J.M. Quattro, M.E. Rogers, P.C. Brunjes, and R.G. Vogt. 1996. Ontogeny of odorant receptor gene expression in the zebrafish, Danio rerio. J. Neurobiol.  29:445-458.


Byrd, C.A. and P.C. Brunjes. 1995. Organization of the olfactory system in the adult zebrafish: Histological, immunohistochemical, and quantitative analyses. J. Comp. Neurol. 358:247-259.


Byrd, C.A. and G.D. Burd. 1993. The quantitative relationship between olfactory axons and mitral/tufted cells is unchanged in developing Xenopus with partially deafferented olfactory bulbs. J. Neurobiol. 24(9):1229-1242.


Byrd, C.A. and G.D. Burd. 1993. Morphological and quantitative evaluation of olfactory-bulb development in Xenopus after olfactory-placode transplantation. J. Comp. Neurol. 331:551-563.


Byrd, C.A. and G.D. Burd. 1993. Analysis of olfactory-bulb development in the frog: Effects of experimental manipulation of afferent number. In: Development, Growth, and Senescence in the Chemical Senses. NIDCD Monographs 3:23-29. NIH Publications: Bethesda, MD.


Byrd, C.A. and G.D. Burd. 1991. Development of the olfactory bulb in the clawed frog, Xenopus laevis: A morphological and quantitative analysis. J. Comp. Neurol. 314:79-90.


Little, J.W., C.A. Byrd, and D.L. Brower. 1990. Effect of abx, bx, and pbx mutations on expression of homeotic genes in Drosophila larvae. Genetics 124:899-908

Western Michigan University

© 2016 by Dr. Byrd-Jacobs. Proudly created with Wix.com

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